課程介紹
1. Translational medicine: Turning Basic Research to Medicines and Treatment. Especially for human interests.
2.PAPER READINGS
´Meng X , Xia C , Ye Q , Nie X . tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells. Food Funct. 2020;11(5):4193-4201.
´Guimbal S, Morel A, Guérit D, Chardon M, Blangy A, Vives V. Dock5 is a new regulator of microtubule dynamic instability in osteoclasts. Biol Cell. 2019;111(11):271-283.
´Cao Y, Gomes SA, Rangel EB, et al. S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest. 2015;125(4):1679-1691. doi:10.1172/JCI73780
´Kaneda T, Nojima T, Nakagawa M, et al. Endogenous production of TGF-beta is essential for osteoclastogenesis induced by a combination of receptor activator of NF-kappa B ligand and macrophage-colony-stimulating factor. J Immunol. 2000;165(8):4254-4263. doi:10.4049/jimmunol.165.8.4254
´Sala K, Raimondi A, Tonoli D, Tacchetti C, de Curtis I. Identification of a membrane-less compartment regulating invadosome function and motility. Sci Rep. 2018;8(1):1164. Published 2018 Jan 18. doi:10.1038/s41598-018-19447-2
3.Activities
´PPT lectures
´Paper reading: Assigned paper
´Scientific writing report: Homework
´Project presentation
4.Grading
´Presence (20%)
´Home work : assigned paper reading report (20%)
´Project presentation (30%)
´TEST online (PAPER READINGS) (30%)
教科書:
Molecular Biology of the Cell, by Alberts. An older free copy of the book can be found here: http://www.ncbi.nlm.nih.gov/books/NBK21054/?term=MOLECULAR%20BIOLOGY%20OF%20CELL
教學進度:
´Animal cell culture: primary culture and cell culture
´Looking at the Structure of Cells in the Microscope
´GPCRs and cAMP-Mediated Signaling Cascades
´Receptor and Non-Receptor Tyrosine Kinases, Growth Factors and Cancer
´Cell signaling
´Cytoskeleton
´Molecular motor
´Invadosome
´Oxidative stress & Autophagy
´Regenerative medicine
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