(中) 本課程將介紹有關毒性藥物及化學物質對體內各系統器官所產生之非增殖性及增殖性(腫瘤)病理變化及理論，包括：神經系統、心血管、血液、泌尿、消化、骨骼、肌肉、內分泌、生殖、感官系統等體內各器官所引起之細胞病理變化及病理學評估之介紹。
(Eng.) This course will introduce the systemic alterations of non-proliferative and proliferative (tumor) lesions of drugs and chemicals in body, including nervous, cardiovascular, urinary, digestive, skeletal muscular, reproductive, and integument systems in animals will be discussed.教材：
Berridge BR, Mowat V, Nagai H, Nyska A, Okazaki Y, Clements PJ, Rinke M, Snyder PW, Boyle MC, Wells MY. 2016. Non-proliferative and proliferative lesions of the cardiovascular system of the rat and mouse. J Toxicol Pathol.;29(3 Suppl):1S-47S.
Creasy D, Bube A, Rijk Ed, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K., Rehm S, Rogerson P, and Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol. 40: 40S-121S.
Dixon D, Alison R, Bach U, Colman K, Foley GL, Harleman JH, Haworth R, Herbert R, Heuser A, Long G, Mirsky M, Regan K, Van Esch E, Westwood FR, Vidal J, Yoshida M. 2014. Nonproliferative and proliferative lesions of the rat and mouse female reproductive system. J Toxicol Pathol. 27(3-4 Suppl):1S-107S.
Fossey S, Vahle J, Long P, Schelling S, Ernst H, Boyce RW, Jolette J, Bolon B, Bendele A, Rinke M, Healy L, High W, Roth DR1 Boyle M, Leininger J. 2016. Nonproliferative and proliferative lesions of the rat and mouse skeletal tissues (bones, joints, and teeth). J Toxicol Pathol. 229 (3 Suppl):49S-103S.
Frazier KS, Seely JC, Hard GC, Betton G, Burnett R, Nakatsuji S, Nishikawa A, Durchfeld-Meyer B, and Bube A. 2012. Proliferative and nonproliferative lesions of the rat and mouse urinary system. Toxicol Pathol. 40: 14S-86S.
Greaves, P., Chouinard, L., Ernst, H., Mecklenburg, L., Pruimboom-Brees, I.M., Rinke, M., Rittinghausen, S., Thibault, S., Von Erichsen, J., Yoshida, T. 2013. Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium. J Toxicol Pathol. 26 (3 Suppl): 1S–26S.
Kaufmann W, Bolon B, Bradley A, Butt M, Czasch S, Garman RH, George C, Gröters S, Krinke G, Little P, McKay J, Narama I, Rao D, Shibutani M, and Sills R. 2012. Proliferative and nonproliferative lesions of the rat and mouse central and peripheral nervous systems. Toxicol Pathol. 40 (4 Suppl):87S-157S.
Mecklenburg L, Kusewitt D, Kolly C, Treumann S, Adams ET, Diegel K, Yamte J, Kaufmann W, Müller S, Danilenko D, and Bradley A. 2013. Proliferative and non-proliferative lesions of the rat and mouse integument. J Toxicol Pathol. 26 (3 Suppl): 27S–57S.
Mann PC, Vahle J, Keenan CM, Baker JF, Bradley AE, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, Nolte T, Rittinghausen S, Tanaka T. 2012. International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol. 40(4 Suppl):7S-13S.
Nolte T, Brander-Weber P, Dangler C, Deschl U, Elwell MR, Greaves P, Hailey R, Leach MW, Pandiri AR, Rogers A, Shackelford CC, Spencer A, Tanaka T, and Ward JM. 2016. Nonproliferative and proliferative lesions of the gastrointestinal tract, pancreas and salivary glands of the rat and mouse. J Toxicol Pathol. 29(1 Suppl):1S-125S.
Rudmann D, Cardiff R, Chouinard L, Goodman D, Küttler K, Marxfeld H, Molinolo A, Treumann S, Yoshizawa K.; INHAND Mammary, Zymbal's, Preputial, and Clitoral Gland Organ Working Group. 2012. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbal's, preputial, and clitoral glands. Toxicol Pathol. Aug;40(6 Suppl):7S-39S.
Renne R, Brix A, Harkema J, Herbert R, Kittel B, Lewis D, March T, Nagano K, Pino, M, Rittinghausen S, Rosenbruch M, Tellier P, and Wohrmann T. 2012. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol. 37: 5S-73S.
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, Nakae D, Gregson R, Vinlove MP, Brix AE, Singh B, Belpoggi F, and Ward JM. 2010. Proliferative and non- proliferative lesions of the rat and moues hepatobiliary system. Toxicol Pathol. 38 (7 Suppl):5S-81S.
Rubcll Z, Arceo RJ , Bishop SP，Elwell MR, Kerns WD, Mesfin GM, Sandusky GE, and Van Vleet JF. 2000. Non-proliferative lesions of the heart and vasculature in rats. CV-l. In: Guides for Toxicologic Pathology, STP/ARP/AFlP. Washington, DC.
Westwood FR. 2008. The female rat reproductive cycle: A practical histological guide to staging. Toxicol Pathol. 36: 375-384.
Willard-Mack CL, Elmore SA, Hall WC, Harleman J, Kuper CF, Losco P, Rehg JE, Rühl-Fehlert C, Ward JM, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler BW, Herbert RA, Keenan CM (2019) Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicol Pathol 47: 665–783
