課程介紹
利用獸醫細胞免疫學及微生物基因毒理學配合分子診斷技術，探討疾病及毒物之細胞之免疫及基因毒理分子作用機制，作為探討疾病及中毒發生，加強學生對免疫疾病及毒物之認知，導引學生研究思考方向。
教科書:
  1. 1. Yamaguchi N, Nakamura K, Oguma Y, Fujiwara S, Takabe M, Sono A, Kawasaki T, Otsubo K, Wakigawa K. 2009. Genotoxicity studies of ubidecarenone (coenzyme Q10) manufactured by bacteria fermentation. J Toxicol Sci. 34: 389-397.
  2. Ames Test. 2007. Encyclopedia of Biopharmaceutical Statistics Second Edition, Informa Healthcare.
  3. Detrick . 2006. Manual of molecular & clinical laboratory immunology, 7th Ed. Elsevier.
  4. Jacques Descotes. 2004. Principle and methods of immunotoxicology. V1.
  5. Preston, R., and Hoffinann. 2006. Genetic toxicology. In: Klassenn, C.D., Ed., Casarett & Doull’s Toxicology. The Basic Science of Poisons, 6th Edition, Unit 3. p. 321-350.McGwraw-Hill, Medical Publishing Division, New York. USA.
  6. Mortelmans K, and Zeiger E. 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat Res. 455(1-2):29-60.
教學進度:
  1. 疾病免疫及微生物基因毒理診斷技術資料之搜尋 (Information research)
  2. 設計與規畫 (Design and planning)
  3. 細胞培養之技術種類 (Techniques of cell culture)
  4. 微生物及細胞培養模式之應用 (Models for microbiology and cell culture)
  5. 微生物基因毒理操作技術 (Operation for genetic toxicology)
  6. 細胞免疫操作技術 (Operation for cellular immunology)
  7. 微生物基因毒理學之研究與趨勢 (Trend and research in genotoxicity)
  8. 細胞免疫作用機制之探討 (Mechanisms for cellular immunology)
  9. 指導研究報告之撰寫及綜合討論 (Research report writing and discussion)
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