課程介紹
本課程之教學目的為提供初學者有關生物資訊學之基本概念，講授核酸及胺基酸資料庫之資訊儲存、擷取、分析及管理等基礎知識，以利學生日後從事相關研究工作，並培訓本土生物資訊技術人才。

本課程概括介紹生物資訊學之基礎知識，並配合上機實際操作。教室內有示範用電腦一部，並提供無線網路，歡迎同學們自備筆記型電腦同步操作。課程內容分為五大部分:

  1. 生物資訊學網路資源簡介(文獻與生物巨分子資料庫、網路分析軟體)
  2. 核苷酸序列分析簡介與操作(網路資源)
  3. 胺基酸序列分析簡介與操作(網路資源)
  4. UNIX及Windows PowerShell操作系統簡介與基礎指令稿語言(scripting language)操作
  5. 蛋白質結構分析簡介與操作

每一部份約二至四週的課程，，使同學能充分了解所學內容，達到”所學即所用”的目標。

教科書:
  1. Baxevanis, A. D. and Ouellette, B. F. F. 1998. Bioinformatics: A practicla guide to the analysis of genes and proteins. John Wiley and Sons, Inc. New York.
  2. Gopal, S., Haake, A., Jones, R. P., Tymann, P. 2009. Bioinformatics: A Computing Perspective. McGraw-Hill International Edition, Taipei.
  3. Claverie, J.-M., and Notredame, C. 2003.  Bioinformatics for Dummies.  Wiley publishing, Inc.  New York, NY, USA.
  4. http://www.ncbi.nlm.nih.gov;
  5. http://workbench.sdsc.edu;
  6. GCG program manual. (http://www.gcg.com/genhelp)
  7. http://www.nhri.org.tw/bioinfo/
教學進度:

Date

Content

Sept. 14

General Introduction

Sept. 21

Sequence Analyses with Distributed Resources: Popular Databases

Sept. 28

Sequence Analyses with Distributed Resources: Nucleotide Sequence analysis — Basics

Oct. 5        

Sequence Analyses with Distributed Resources: Nucleotide Sequence analysis — Single sequence analyses

Oct 12

Sequence Analyses with Distributed Resources: Nucleotide Sequence analysis — Pair-wise sequence analyses

Oct. 19

   

Sequence Analyses with Distributed Resources: Nucleotide Sequence analysis — Multiple sequence analyses

Oct. 26       

Sequence Analyses with Distributed Resources: RNA sequence analysis

Nov 2    

PC-based Bioinformatics Tool Kit: BioEdit, Basic Scripting

Nov.9    

PC-based Bioinformatics Tool Kit: BioEdit, Basic Scripting

Nov.16  

PC-based Bioinformatics Tool Kit: FASTA,

Nov.23  

PC-based Bioinformatics Tool Kit: GeneDoc, MEGA

Nov 30

PC-based Bioinformatics Tool Kit: GeneDoc, MEGA

Dec 7    

Protein Structure and Function – Primary structure

Dec.14  

Protein Structure and Function – Secondary structure

Dec.21  

Protein Structure and Function – Tertiary structure

Dec.28  

Protein Structure and Function – Tertiary structure

Jan  4

Protein Structure and Function – Animation

Jan 11

(*Final reports due!!!)
本課程不開放報名