課程介紹

(中) 本課程將介紹有關毒性化學物質所引發動物產生病理現象及理論，包括：毒物之吸收、分佈、代謝及排出，對體內各器官所引起之細胞反應或致癌作用，實驗動物模式及病理學評估之介紹。

(Eng.) This course will introduce the advanced mechanisms and hypothesis of toxic mechanisms, and further studies of toxicity assays, including absorption, distribution, metabolism and excretion in body. Finally, cellular and carcinogenic responses in animals will be discussed.
教科書:
  1. The UFAW Handbook on the Care and Management of Laboratory Animals. Vol. 1~2, T. Poole Ed., Blackwell Science, 7th Edition. 1999.
  2. Handbook of Laboratory animal science, Vol.1~ P. Svendsen and J. Hau Eds, CRC Press, 1994.
  3. Casarett & Doull’s Toxicology. 2007. The Basic Science of Poisons, Klaassen, C. D. Ed., 6th ed., International Edition, McGraw-Hill, New York, USA.
  4. Mann, P.C., Hardisty, J. F., and Parker, M.D. 2001. Handbook of Toxicologic Pathology, Haschek, W. M., Rousseaux, C.G., and Wallig, M. A., Eds., Two-Volume Set, pp. 187-206, Elsevier Science & Technology Books.
  5. A joint publication of the RITA and NACAD groups. 2011. Revised guides for organ sampling and trimming in rats and mice –Part 1, 2, 3. Toxicologic Pathology.
Yu JYL, Cheng CK, Chen BJ, Cheng MJ, Cheng HH, Chang WJ, Chen HHC, Hong CC, Lee PJ, Liang SC, Sheu KS, Sung YY, Weng CN, Tsai CW, Wang CS, Wang MH, Yen LS, Yu CK. 2005. A guideline for the care and use of laboratory animals. Published by the Chinese Society for the Laboratory Animal Science, 3rd edition, Taipei, Taiwan, ROC (in Chinese).
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